Abstract:In recent years, the organometallic and coordination chemistry of the alkali and alkaline earth metals has experienced tremendous progress to tackle the needs of today's society. Enhanced ecological awareness and global availability favor research on the chemistry of the essential s-block metals. Nowadays, the s-block metals are conquering new chemical fields based on sophisticated theoretical and preparative achievements. Recent investigations show a huge impact of the s-block elements on stoichiometric and catalytic processes.Keywords: s-block metals; catalysis; Grignard reagents; alkali metals; alkaline earth metals The s-block metals subsume the elements of the first two groups of the periodic table-the alkali and alkaline earth metals. The non-radioactive elements were all discovered by the middle of the 19th century  (Table 1), initiating a profound s-block metal-based chemistry with a very long tradition. Generally, the toxicity is low and highly toxic congeners are limited to the radioactive metals and beryllium , justifying the underrepresented extent of their chemistry.