The aim of the work was to study the effectiveness of remaxol inclusion in treatment regimens designed for patients with comorbid tuberculosis and hepatotoxic response to etiotropic therapy.Materials and Methods. Case histories of 25 patients (21 men and 4 women) with a confirmed diagnosis of tuberculosis infection and hepatotoxic reactions to etiotropic treatment were analyzed. Of these, 9 patients had a comorbid (TB/HIV) pathology and 16 patients had TB/HIV with concomitant diseases. To stop the signs of hepatotoxicity, all patients were prescribed with remaxol: 400 ml intravenously on alternate days (course No. 5), then 1 time per week (course No. 4). In addition to the standard clinical and laboratory examination, all patients underwent follow-up (before and after the course of remaxol) examination of the levels of aspartate aminotransferase and total bilirubin in the blood, as well as the levels of interleukin production (1β, 4, 6 and 10) and tumor necrosis factors (TNF-α and TNF-γ). Standard regimens were used when conducting anti-tuberculosis chemotherapy.Results. It was noted that the presence of a comorbidity aggravates the course of tuberculosis and reduces the effectiveness of etiotropic therapy due to the development of hepatotoxicity. The inclusion of remaxol contributed to a decrease in the severity of hepatotoxic reactions and made it possible to avoid the correction of the main treatment course. The revealed positive dynamic in cytokine profile indicators can be regarded as a mediated immunological effect of the drug and requires further research.
Рассмотрена проблема оценки качества программного обеспечения информационных систем. Исследованы существующие метрики качества программ, проведен анализ достоинств и недостатков методов оценки качества ПО. Рассмотрена система потребительских свойств программного обеспечения. Предложена процедура оценки качества ПО, включающая выбор свойств, формирующих качество ПО и измерение значений показателей качества. Предложен метод многокритериального оценивания качества программных продуктов Ключевые слова: программное обеспечение, информационные системы, качество, характеристики программ, процедура, многокритериальное оценивание The problem of quality evaluation for software of information systems is considered. The existent birthcertificates of quality of the programs are investigated, analysis of dignities and lacks of methods for quality evaluation of software is conducted. The system of consumer properties of software is considered. Procedure of quality evaluation for software is offered, including the choice of properties that formed quality of software and measurement of values of quality indexes. The method of multicriterion quality evaluation for software products is offered
References 1. Osoblivostі organіzatsії primіskih zalіznichnih pasazhirskih transported.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.