The article presents the data of scientific research on the features of the application of the method of deep oscillation by pulsed low-frequency electrostatic field (low-frequency electrostatic massage) in the early rehabilitation period after surgical interventions and in various diseases.
Background. According to current epidemiological studies, 94.9% of women suffering from sexually transmitted infections are diagnosed with the presence of human papillomavirus (HPV) DNA during the examination.
Aims. The aim of the study was to study the effect of combined exposure to blue monochromatic polarized incoherent light and polychromatic visible and infrared polarized light in combination with imihimod 5% cream for external use on the state of systemic immunity in patients with HPV-associated cervicitis.
Materials and methods. The study included 60 patients aged 2035 years with an HPV-associated cervicitis with a history of at least 1 year, who were randomly divided into 3 groups: in the main group (n=20), course effects of blue monochromatic polarized incoherent light on the projection of the carotid arteries and polychromatic visible and infrared polarized light on the cervix in combination with imihimod 5% cream for external use (complex 1); in the comparison group (n=20) exposure to polychromatic visible and infrared polarized light on the cervix in combination with imihimod cream for external use 5% (complex 2); in the control group (n=20) a course of local exposure to the cervix with imihimod cream 5%. The data of the survey of 20 healthy women of the same age were taken as the values of the norm. The state of systemic immunity in patients with HPV-associated cervicitis before treatment and after the course was evaluated by the indicators of mature T-lymphocytes (CD3+), CD4+, CD8+, immunoregulatory index (IRI = CD4+/CD8+), CD16+ (natural killer cells) and CD20+ (B-mature lymphocytes) in peripheral blood.
Results. Before the start of treatment, the patients showed low levels of CD3+-lymphocytes and a decrease in the immunoregulatory index, which is the ratio of CD4+/CD8+ against the background of an increase in the relative content of CD16+ and CD20+, which indicates an imbalance in the cellular immunity. After the course of treatment, the most pronounced results were obtained under the influence of complex 1: a significant increase in the relative content of CD3+ and normalization of IRI against the background of a decrease to the reference values of the initially elevated levels of CD16 (%) and CD20 (%) in both the percentage and absolute ratio of these populations in peripheral blood. Patients treated with complex 2 also showed a positive, but less pronounced, trend towards an increase in CD3+ and IRI and a decrease in elevated CD16+ levels after the course of treatment. In the control group, there was no statistically significant difference between the indicators before and after treatment, and only a slight positive trend was observed for some of them.
Conclusion. The combined use of blue monochromatic polarized incoherent light on the projection of the carotid arteries in combination with polychromatic visible and infrared polarized light and imihimod 5% cream for external use on the cervix in patients with chronic cervicitis associated with papillomavirus infection, to a greater extent than the local use of polarized light in combination with imihimod 5%, has a pronounced immunocorrective effect on the cellular link of immunity.
The authors present the results on application retinoid in the dose of 10-20 mg in a combination with ultra-violet therapy for treatment of patients with a widespread form of Devergie’s disease. High efficiency and safety of the combined pharmacological and physiotherapeutic method is shown.
This paper presents the data on efficiency of ultrasonic therapy with Interferon and laser therapy in treatment of patients with vulgar warts. The authors studied the effectiveness of the ultrasonic and laser therapy in treatment of patients with clinical manifestations of papilloma virus infection. The examination involved 32 patients aged from 16 to 65. The duration of the disease varied from 2 months to 3 years. After ultrasonic and laser therapy it was established the normalization of laboratory indices. Relapses were absent in 32 patients. Adverse side effects didn’t register during the investigation. The use of ultrasonic and laser therapy allows to carry out highly effective therapies in treatment of patients with human papilloma virus disorders, and to decrease the risk of relapse of infection.
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