EA), percutaneous laser ablation (PLA), microwave ablation (MWA), and radiofrequency ablation (RFA), were suggested as an alternative to open PTMC surgery for high-risk patients because of good long-term results [2,3]. Using US-guided PLA, a very small percentage of cases show aggressive behaviour with either lymph node or distant metastases during long-term follow-up [5]. This method was recommended by the European Thyroid Association and the American Association of Clinical Endocrinologists in the 2010 Thyroid Nodule Guidelines and the 2020 European Thyroid Association Clinical Practice Guideline as an effective treatment alternative in benign thyroid nodules, based on a clinically significant decrease in nodule volume and the amelioration of local symptoms, safety, and clinical efficacy. PLA is also recommended for patients who decline surgery or are at surgical risk. [7] In this review, we focus on US-guided PLA for PTMC treatment.
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