Purpose. The purpose of this study is to analyze the effect of preoperative waiting time on the short-term outcomes and prognosis in colorectal cancer (CRC) patients. Methods. We retrospectively analyzed 3744 CRC patients who underwent primary CRC surgery at a single clinical medical center from Jan 2011 to Jan 2020. The baseline information, short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared among the short-waiting group, the intermediate-waiting group, and the long-waiting group. Results. A total of 3744 eligible CRC patients were enrolled for analysis. There were no significant differences in all of the baseline information and short-term outcomes among the three groups. In multivariate analysis, older age (OS: p = 0.000 , HR = 1.947, 95% CI = 1.631–2.324; DFS: p = 0.000 , HR = 1.693, 95% CI = 1.445–1.983), advanced clinical stage (OS: p = 0.000 , HR = 1.301, 95% CI = 1.161–1.457; DFS: p = 0.000 , HR = 1.262, 95% CI = 1.139–1.400), overall complications (OS: p = 0.000 , HR = 1.613, 95% CI = 1.303–1.895; DFS: p = 0.000 , HR = 1.560, 95% CI = 1.312–1.855), and major complications (OS: p = 0.001 , HR = 1.812, 95% CI = 1.338–2.945; DFS: p = 0.006 , HR = 1.647, 95% CI = 1.153–2.352) were independent factors of OS and DFS. In addition, no significant difference was found in all stages (OS, p = 0.203 ; DFS, p = 0.108 ), stage I (OS, p = 0.419 ; DFS, p = 0.579 ), stage II (OS, p = 0.465 ; DFS, p = 0.385 ), or stage III (OS, p = 0.539 ; DFS, p = 0.259 ) in terms of OS and DFS among the three groups. Conclusion. Preoperative waiting time did not affect the short-term outcomes or prognosis in CRC patients.
Purpose. The current study was designed to investigate the impact of blood urea nitrogen (BUN), serum uric acid (UA), and cystatin (CysC) on the short-term outcomes and prognosis of colorectal cancer (CRC) patients undergoing radical surgery. Methods. CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in a single clinical centre. The short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared in different groups. A Cox regression analysis was conducted to identify independent risk factors for OS and DFS. Results. A total of 2047 CRC patients who underwent radical resection were included in the current study. Patients in the abnormal BUN group had a longer hospital stay ( p = 0.002 ) and more overall complications ( p = 0.001 ) than that of the normal BUN group. The abnormal CysC group had longer hospital stay ( p < 0.01 ), more overall complications ( p = p < 0.01 ), and more major complications ( p = 0.001 ) than the normal CysC group. Abnormal CysC was associated with worse OS and DFS for CRC patients in tumor stage I ( p < 0.01 ). In Cox regression analysis, age ( p < 0.01 , HR = 1.041, 95% CI = 1.029–1.053), tumor stage ( p < 0.01 , HR = 2.134, 95% CI = 1.828–2.491), and overall complications ( p = 0.002 , HR = 1.499, 95% CI = 1.166–1.928) were independent risk factors for OS. Similarly, age ( p < 0.01 , HR = 1.026, 95% CI = 1.016–1.037), tumor stage ( p < 0.01 , HR = 2.053, 95% CI = 1.788–2.357), and overall complications ( p = 0.002 , HR = 1.440, 95% CI = 1.144–1.814) were independent risk factors for DFS. Conclusion. In conclusion, abnormal CysC was significantly associated with worse OS and DFS at TNM stage I, and abnormal CysC and BUN were related to more postoperative complications. However, preoperative BUN and UA in the serum might not affect OS and DFS for CRC patients who underwent radical resection.
Purpose. The purpose of the current study is to analyze whether preoperative hyponatremia affected the short-term outcomes of colorectal cancer (CRC) surgery. Methods. This retrospective study was conducted in a single clinical center where we enrolled patients who underwent primary CRC surgery from January 2011 to December 2021. The short-term outcomes were compared between the hyponatremia group and the normal sodium group using propensity score matching (PSM) analysis. Results. A total of 6730 cases of patients who received CRC surgery were finally included in this study. There were 184 patients in the hyponatremia group and 6546 patients in the normal sodium group. After 1 : 1 ratio PSM, 184 patients in the normal sodium group were matched to 184 patients in the hyponatremia group. No significant difference was found in baseline information after PSM (P > 0:05). After PSM, the hyponatremia group had higher patients with overall complications (P = 0:013). Univariate and multivariate logistic regression analysis were conducted to find predictors of complications, and we found that older age
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