Tumor microenvironment with hypoxia and excess hydrogen peroxide (HO) tremendously limits the effect of chemoradiation therapy of colorectal cancer. For the first time, we developed a facile method to deposit manganese dioxide (MnO) on the surface of albumin bound paclitaxel nanoparticles (ANPs-PTX) to obtain MnO-functioned ANPs-PTX (MANPs-PTX). In the tumor microenvironment, MANPs-PTX could consume excess hydrogen peroxide (HO) to produce abundant oxygen for tumor oxygenation and improve chemoradiation therapy. Meanwhile, the released Mn from MANPs-PTX had excellent T magnetic resonance imaging (MRI) performances for tumor detection. Notably, the obtained MANPs-PTX would be a promising theranostic agent and have potential clinical application prospects.
A biofunctional liposome containing acriflavine (ACF) and doxorubicin (DOX) for reducing the chemotherapy resistance of DOX induced by reactive oxygen species.
We utilized albumin as reducing agent to establish a novel pH-sensitive nanocarrier with abundant Cu+, which can encapsulate HDAC inhibitor vorinostat to form uniform V-CuNPs for synergistic chromatin remodelling and chemodynamic therapy.
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