The feature points of skull location and mark is an important research aspect in computer-aided facial Reconstruction and computer-aided photographic superimposition. Based on technique in the topology between feature points analyzing, an automatic localization and marking method for key points of skull is proposed. First, get the contour of skull based on image preprocess technique and calculate the centroid of skull. Then according to the relationship between skull centroid and the centre point of orbital cavity, the centre point of orbital cavitiey is obtained. Finally, key points are located according to SUSAN operator and the topology between feature points. Experimental results prove that this method is efficient and better accuracy can be obtained.

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