An FeCl 3 -catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water is described, which provides an environmentally benign, efficient, and practical route for the generation of 2-aminobenzothiazole. This present tandem process shows broad substrate scope in the presence of octadecyltrimethylammonium chloride as a phase-transfer catalyst. In addition, the reaction media can be recovered and recycled without loss of efficiency.
A copper-catalyzed hydroxysulfenylation of α,β-unsaturated esters/amides is reported. The method presents a selective and efficient synthesis of β-hydroxysulfides bearing electron-withdrawing groups. The synthetic utility of this method is demonstrated by the concise synthesis of the anticancer drug bicalutamide.
An alkyl‐Heck‐type cross‐coupling reaction is developed by manganese‐catalyzed oxidative decarbonylation of aldehydes. A variety of primary, secondary, and tertiary aliphatic aldehydes can participate in this alkenylation. The reaction is initiated by an alkyl radical, which is generated by oxidative decarbonylation of the aldehyde.
2 become 1: α,β‐Epoxy‐γ‐butyrolactones were synthesized efficiently and selectively through the nucleophilic cyclization of cis‐α‐ester‐β‐keto epoxides, which were obtained by an amine‐catalyzed diasteroselective cyclization of 2‐peroxy‐1,4‐dicarbonyl compounds under mild reaction conditions.
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