In this paper, we address a novel task, namely weakly-supervised spatio-temporally grounding natural sentence in video. Specifically, given a natural sentence and a video, we localize a spatio-temporal tube in the video that semantically corresponds to the given sentence, with no reliance on any spatio-temporal annotations during training. First, a set of spatiotemporal tubes, referred to as instances, are extracted from the video. We then encode these instances and the sentence using our proposed attentive interactor which can exploit their fine-grained relationships to characterize their matching behaviors. Besides a ranking loss, a novel diversity loss is introduced to train the proposed attentive interactor to strengthen the matching behaviors of reliable instance-sentence pairs and penalize the unreliable ones. Moreover, we also contribute a dataset, called VID-sentence, based on the Im-ageNet video object detection dataset, to serve as a benchmark for our task. Extensive experimental results demonstrate the superiority of our model over the baseline approaches. Our code and the constructed VID-sentence dataset
Murine macrophages (M phi) are activated either by interferon-gamma (IFN-gamma) or interferon-alpha/beta (IFN-alpha/beta) in combination with bacterial lipopolysaccharide (LPS) to induce synthesis of tumor necrosis factor alpha (TNF-alpha) and nitric oxide synthase (iNOS) mRNA synthesis for generation of tumor cytotoxic nitric oxide (NO). In the present study, the effect of exogenous IFN-gamma on the induction of endogenous mRNA synthesis and secretion of IFN-alpha/beta by murine M phi was investigated. Neutralizing antibodies to IFN-alpha/beta reversed TNF-alpha and NOS mRNA synthesis, as well as nitric oxide (NO)-mediated tumor cytotoxicity. Quantitative reverse transcription polymerase chain reaction (RT-PCR) revealed that treatment of M phi with IFN-gamma induced increases in both IFN-alpha and IFN-beta mRNA synthesis by approximately 2-fold and 10-fold, respectively, which corresponded to a 2-fold increase in secretion of IFN-alpha/beta by ELISA. These data indicate that exogenous IFN-gamma induces endogenous synthesis and secretion of IFN-alpha/beta by M phi, which appears to act in concert with endogenously synthesized TNF-alpha for the autocrine induction of NOS mRNA synthesis.
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