Background: BRD4 interacts with P-TEFb, which regulates Pol II elongation. Results: Disruption of BRD4 binding by JQ1 resulted in reduced Pol II Ser-2 in CD4ϩ T cells. Conclusion: BRD4 affects Pol II Ser-2 phosphorylation at a subset of lineage-specific active genes in primary human CD4ϩ T cells. Significance: BRD4 binding may represent a means of identifying active promoters and lineage-specific enhancer elements.
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