Multiresistant bacteria represent a global health problem, encouraging the development of effective antimicrobial treatments. In this context, metallic nanoparticles like silver nanoparticles (AgNPs) can serve as an alternative to the pathogenic bacterial growth control since AgNPs
have minimal risk of promoting bacterial resistance. The chemical methods to synthesize AgNPs involves toxic agents however, an alternative way to obtain them would be employing plant extract due to its redox ability. In the current study, Spondias tuberosa hydroethanolic leaf extract
(StHE) was used to assist silver nanoparticle synthesis (AgNP) and to evaluate the antimicrobial effect of both StHE and AgNP against antibiotic-resistant bacterias Pseudomonas aeruginosa and Staphylococcus aureus. The StHE phytochemical analysis displayed
significant polyphenol and flavonoids contents, identified by HPLC. Synthesized AgNPs were spherical with an average size of 3.44–19.46 nm, characterized by UV-Vis and transmission electron microscopy (TEM). The AgNPs antimicrobial activity displayed higher capacity than the crude StHE,
mainly against Gram-negative bacteria. Therefore, StHE is an effective source of reducing agents for the AgNPs synthesis, which exhibit high antibacterial potential against multidrug-resistant bacteria.
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