Virus-like particles (VLPs) are virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the form and size of a virus particle but lacking the genetic material so they are not capable of infecting the host cell. Expression and self-assembly of the viral structural proteins can take place in various living or cell-free expression systems after which the viral structures can be assembled and reconstructed. VLPs are gaining in popularity in the field of preventive medicine and to date, a wide range of VLP-based candidate vaccines have been developed for immunization against various infectious agents, the latest of which is the vaccine against SARS-CoV-2, the efficacy of which is being evaluated. VLPs are highly immunogenic and are able to elicit both the antibody- and cell-mediated immune responses by pathways different from those elicited by conventional inactivated viral vaccines. However, there are still many challenges to this surface display system that need to be addressed in the future. VLPs that are classified as subunit vaccines are subdivided into enveloped and non- enveloped subtypes both of which are discussed in this review article. VLPs have also recently received attention for their successful applications in targeted drug delivery and for use in gene therapy. The development of more effective and targeted forms of VLP by modification of the surface of the particles in such a way that they can be introduced into specific cells or tissues or increase their half-life in the host is likely to expand their use in the future. Recent advances in the production and fabrication of VLPs including the exploration of different types of expression systems for their development, as well as their applications as vaccines in the prevention of infectious diseases and cancers resulting from their interaction with, and mechanism of activation of, the humoral and cellular immune systems are discussed in this review.

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The impact of education on the prevention of vaginal infection ... [22] Application of PRECEDE-PROCEED Planning model ... [23] Application Precede-Proceed health promotion model ... [24] Adolescent idiopathic scoliosis screening for ... [25] Predicting of Factors influencing physical activity in women ... [26] Effectiveness of PRECEDE model for health education ... [27] Investigating the Effect of educational program based ... [28] Survey of the effect of educational intervention ... [29] Effects of self-guided e-counseling on health behaviors and ... AimsHypertension is one of the most common chronic health problems worldwide and selfcare behaviors are an important part of managing blood pressure in these patients. Therefore, the present study was conducted to determine the effect of educational intervention based on the PRECEDE model on the promotion of self-care behaviors of patients with hypertension.Materials & Methods This randomized controlled trial was performed among 102 patients with hypertension who were selected by multi-stage cluster sampling in 2018. Data collection tools included demographic information and a standard questionnaire based on the PRECEDE model constructs which were completed by interview. The experimental group participated in 4 training sessions. Questionnaires were collected before and 3 months after the educational intervention from the participants of the experimental and control groups. Data were analyzed in SPSS 19 software using Chi-square, independent t-test, paired t-test, and linear regression. Findings The results showed that knowledge, attitude and enabling factors predicted 20% of the variance of self-care behaviors of patients with hypertension before the educational intervention. After the educational intervention, the mean scores of all structures of the PRECEDE model were statistically significant between the experimental and control groups (p<0.05), except for the enabling factors (p>0.05). Also, the mean score of self-care behaviors 3 months after the educational intervention in the experimental group was significantly increased compared to the control group (p<0.05). Conclusions Increasing the average of self-care behavior in patients undergoing educational intervention indicates the effective role of education in the use of self-care behaviors. Proper planning for educational interventions based on the PRECEDE model as well as providing the necessary structures is necessary to facilitate the realization of self-care behaviors in patients with hypertension.

Background: In recent years, an increased incidence of breast cancer has made this disease the most common malignancy among Iranian women. Since education plays an important role in the implementation of preventive behaviors in breast cancer treatment, this study investigates the effect of educational interventions on the promotion of lifestyle-related behaviors that prevent breast cancer in middle-aged women. Methods: In this randomized control study, 120 women referred to Neyshabur Health Services Centers were randomly selected and divided into two groups: an intervention group (60 subjects) and a control group (60 subjects). An educational intervention was carried out over five sessions, based on protective motivation theory constructs. Participants completed a researcher-designed questionnaire immediately and again 2 months after the intervention. The data were analyzed using IBM SPSS ver. 19.0 software (IBM Corp., Armonk, NY, USA). Results: The results revealed a significant difference between the mean scores of participants exposed to protective motivation theory, awareness, and physical activities immediately and also 2 months after the intervention (P<0.05). Although the healthy diet scores of the two groups differed significantly immediately after the educational intervention (P<0.05), there was no significant difference between the groups 2 months after the intervention (P<0.05). Conclusion: Given the effective role of education in protective motivation theory and the physical activity levels of the women who participated in this research, it seems clear that the women's financial status shaped their ability to consume more fruits and vegetables. As this social element impacts the health of individuals, training programs alone cannot succeed.

Background: Exploration of the efficiency of metal nanoparticles as adjuvants have reported varying results. Objective: The efficacy of metal nanoparticles as adjuvants was investigated Data sources: Database were searched using the terms ‘metal nanoparticles’ and ‘vaccines’. Study eligibility criteria: Studies in animal models utilizing any metal-based vaccines, where the survival rate was described. Study appraisal: The quality of the studies was examined using aspects of the ARRIVE guidelines and assessment of the risk of bias of included studies. Results: Metal nanoparticle-based adjuvants were more effective compared with control (unvaccinated groups) but have not been more successful in competing with common adjuvants or even antigens alone. Limitation: More than 75% of articles have used only gold nanoparticles. Conclusion: Nano-adjuvants do not have a significant effect on reducing mortality.