The aim of the present study was to examine the factor structure and psychometric properties of the 8-item short version of the Center for Epidemiologic Studies-Depression Scale (CES-D) in a large sample of European older adults. Data from The European Social Survey (ESS Round 6 Edition 1.1) provided the basis for this study (5,774 Males and 7,258 Females). Exploratory and confirmatory factor analyses provided support for a single factor structure. The results from multi-group confirmatory factor analyses revealed that the factor structure of the CES-D 8 is invariant across sexes, including invariance of item intercepts, item residuals, and item factor loadings. Moreover, the results provided support for the nomological validity of the scale. These results suggest that the shorter 8-item CES-D scale is a valid and reliable instrument of depression and extends the list of available instruments for screening depression among older adults.

No abstract

Moringa oleifera is also known as “Miracle tree”, due to its multiple uses and adaptability. Because of nutritive and pharmacological values, it is widely cultivated across the world. M. oleifera leaves are rich source of minerals, vitamins and many health beneficial secondary metabolites, and possess significant anti-diabetic potential. Consequently, Insilco study could be noteworthy to expand effective anti-diabetic drugs from this plant. Present study was designed to find out the best bioactive compounds of M. oleifera as a potential therapeutic agent against diabetes mellitus through In-silico method. For this, structures of phytochemicals were extracted from PubChem and docked to mutated protein from PBD. Afterwards, datasets were prepared for ligand based pharmacophore and their pharmacophoric features were generated from LigandScout. Finally five phytochemicals viz. anthraquinone, 2-phenylchromenylium (Anthocyanins), hemlock tannin, sitogluside (glycoside) and A-phenolic steroid were selected, which exhibited effective binding within the active binding pocket of the targeted protein. Ligand based pharmacophore model showed the key features i.e. HBD, HBA, aromatic ring, hydrophobic, positively ionizable surface essential for receptor binding. Our findings suggest that screened phytochemicals present in M. oleifera can be used as potential therapeutic drug candidates to treat diabetes mellitus.

No abstract

No abstract