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Globally prostate cancer is the second most familiar and fifth-most hostile neoplasm among male individuals. One of the emerging issues in men is prostate cancer. The Prostate is a ductal small walnut-shaped gland situated in men below the urinary bladder that produces the seminal fluid for sperms provision and transportation. The risk of emerging prostate cancer during the man’s lifetime is one out of seven. According to the epidemiological studies, different environmental and genetic factors are associated with the progression of abnormal prostate cell growth which ultimately causes the development of cancerous cells. The chances of prostate cancer occurrence are more in those patients with familial member’s history, and it can be more by two to three-folds associated with first-rank relatives to get prostate cancer. In the current review different risk factors which are associated with the development of prostate cancer, are discussed. Keywords: Prostate cancer, Risk factors, Male, BRCA1, BRAC2.