Atypical fibroxanthoma represents a low-grade sarcoma that usually presents in the elderly population on sun-damaged areas of the head and neck regions. This neoplasm is characterized on histology by atypical pleomorphic, epithelioid to spindled cells, arranged in a haphazard pattern, set within a background of solar elastosis. In this case report, we present a unique case of the rare variant of clear-cell atypical fibroxanthoma arising in an unusual place, specifically the lower extremities.
We report a case of a malignant melanoma clinically mimicking a blue nevus. The patient presented for evaluation of a “seborrheic keratosis” status post cryotherapy that clinically resembled a blue nevus albeit with concerning clinical course prompting biopsy. Histopathologic examination revealed malignant melanoma in association with a melanocytic nevus to include areas resembling tumoral melanosis which likely contributed to clinical presentation. We conclude this report with a brief review on the topic of melanoma masquerading as benign lesions (e.g., blue nevus), underscoring the importance of clinical history and histological examination in the evaluation of this entity.
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