A metal-free photo-oxidative intermolecular C-H/C-H coupling reaction of thiophenes is demonstrated with carbonyls using a catalytic amount of molecular iodine. In this system, molecular oxygen in the air acted as a terminal oxidant to regenerate molecular iodine. A mechanistic study was also performed.
We have achieved ar are-metal-free photo-aerobic intramolecular dehydrogenative coupling reactionf rom two C-H bonds of indole with malonate.T his catalytic system proceeded at room temperature under visible light irradiationw ith oxygen in the air as at erminalo xidant, and the cyclization productsw ere obtained in good to excellent yields.
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