ObjectiveTo assess the effectiveness of resistin in predicting the severity of acute pancreatitis.MethodsPatients with acute pancreatitis who presented at the Gastroenterology Clinic, Erzurum Education and Research Hospital, Turkey were enrolled in this prospective study. White blood cell (WBC), C-reactive protein (CRP) and resistin levels were measured on admission and at 24 h, day 3 and day 7 following admission, along with other blood parameters. Patients were divided into two groups: mild acute pancreatitis and moderate/severe acute pancreatitis.ResultsOf 59 patients with acute pancreatitis (mild, n = 37; moderate/severe, n = 22), significant between-group differences were found in terms of resistin and CRP levels. Receiver operating curve analysis showed that resistin levels were better for predicting severe cases of acute pancreatitis than CRP or WBC levels on day 3 (area under the curve [AUC], 0.88 versus 0.81 and 0.63, respectively). Resistin levels on day 3 were better than CRP levels for predicting necrosis development (AUC, 0.70 versus 0.69, respectively).ConclusionsResistin may represent a new, effective indicator to predict the severity of acute pancreatitis and presence of necrosis in patients with acute pancreatitis.
Aim: Isolated male hypogonadotropic hypogonadism can be congenital or acquired. Mean platelet volume (MPV), which is a determinant of platelet function, is an independent risk factor for cardiovascular disease. The aim of this study was to evaluate MPV values in untreated, normosmic, isolated,male, idiopatic hypogonadotropic hypogonadism (IHH) patients,and MPV the relationship betweenlow testosterone levels, metabolic syndrome, impaired fasting glucose (IFG) ,cardiovascular risk in these patients Materıal and methods: 31 patients with untreated, normosmic, isolated, male, idiopatic hypogonadotropic hypogonadism mean age 22 ± 4.931, 30 healthy control mean age 22.5 ± 7.5 who came to Erzurum Region Education and Research Hospital, outpatient clinic of Endocrinology were included in the study. Patient group and the control group were matched for age, BMI. It was used the IDF criteria (2005) for diagnosis of metabolic syndrome, and the ADA criteria (2007) for diagnosis of impaired fasting glucose. All hormonal analyses were done by chemiluminesance assay.All the study subjects were evaluated by biochemical and platelet parameters. Hypogonadotropic Hypogonadism was defined as total testosterone less than 229 ng/dL, absent or inadequate aspituitary gonadotropins. Result: The MPV levels were also significantly higher in IHH patients than controls (8.6±0.65 and 7.6±0.54 fL, respectively; P=0.000). To assess the correlation with MPV, a Pearson correlation analysis was performed on each variable. MPV had a positive correlation between metabolic syndrome (r=0.
Isolated male hypogonadotropic hypogonadism (IHH) can be congenital or acquired. Mean platelet volume (MPV), determinant of platelet function, is an independent risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate MPV values in male IHH and the relationships between MPV, low testosterone levels, metabolic syndrome, impaired fasting glucose (IFG) and cardiovascular risk. Thirty-one patients with untreated, normosmic, isolated, male IHH (mean age 22.5 ± 7.58 years) and 30 age and BMI-matched healthy individuals (mean 22.51 ± 4.94 years) were included in the study. All hormonal analyses were done by chemiluminesance assay. All study participants were evaluated by biochemical and platelet parameters. MPV were significantly higher in IHH than controls (8.6 ± 0.65 and 7.6 ± 0.54 fl, respectively; P = 0.000). MPV had a positive correlation between metabolic syndrome (r = 0.444; P = 0000), IFG (r = 0.371; P = 0.04), insulin (r = 0.820; P = 0.02), homeostasis model assessment (HOMA)-IR (r = 0.822; P = 0.0023) and BMI (r = 0.373; P = 0.012). MPV had a negative correlation between total testosterone (r = -0.586; P = 0.0000), free testosterone (r = -0.634; P = 0.0000), luteinizing hormone (r = -0.471; P = 0.0000) and FSH (r = -0.434; P = 0.0000). Although control patients did not have metabolic syndrome and IFG, IHH patients had metabolic syndrome and IFG significantly more often (P < 0.001, P = 0.003, respectively). Age, metabolic syndrome, IFG, BMI, fasting glucose, insulin, CRP and HOMA-IR were independent predictive factors of MPV in the multiple regression analysis. These results suggest that men with IHH are susceptible to increased platelet activation and increased MPV values that contribute to an increased risk of cardiovascular complications. From this study, it has been observed that IHH with low testosterone may be a feature of the metabolic syndrome, IFG, increased MPV levels and cardiovascular risk in young adult males.
Objective: Inflammation plays a critical role in the development and progression of cancer. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are easily accessible basic inflammatory parameters. In this study, we aimed to analyze the association between the NLR, PLR, and the Gleason score in prostate cancer, which is main parameter used in the prostate cancer prognosis.Materials and Methods: A total of 173 patients with prostate cancer (mean age, 63±6.2 years) who underwent radical prostatectomy were included into this retrospective study. The NLR and PLR were derived from the complete blood cell count results from the preoperative period. Patients were divided into two groups, as the low grade prostate cancer (Gleason score≤7 [3+4]) and the high-grade prostate cancer (Gleason score≥7 [4+3]) group. A logistic regression analysis was performed to determine the association.Results: A univariate logistic regression analysis showed that the Ln-prostate specific antigen (PSA) (1.83, 95% confidence interval [CI] [1.01, 3.3] p=0.04), Ln-lymphocyte (0.38, 95% CI [0.15, 0.94] p=0.03), and Ln-NLR (1.9, 95% CI 1.9 [1.13, 3.38] p=0.01) levels were significantly associated with the high-grade Gleason score. However, the Ln-PLR levels revealed the association with marginal statistical significance (2.06, 95 % CI [0.95, 4.4] p=0.06). In multiple analyses, after adjusting the analysis for age, 95% CI [1.12, 3.42] p=0.01) and Ln-lymphocyte levels (0.38, 95% CI [0.15, 0.97] p=0.04) were still statistically significantly associated with high-grade prostate cancer. Conclusion:Higher NLR levels were significantly associated with high-grade prostate cancer. However, PLR levels were not a significant predictor of higher Gleason scores.
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