The Deltex (DTX) family is involved in ubiquitination and acts as Notch signaling modifiers for controlling cell fate determination. DTX promotes the development of the ubiquitin chain via its RING finger (DTX_RING). In this study, the solution structure of DTX_RING was determined using nuclear magnetic resonance (NMR). Moreover, by experiments with a metallochromic indicator, we spectrophotometrically estimated the stoichiometry of zinc ions and found that DTX_RING possesses zinc‐binding capabilities. The Simple Modular Architecture Research Tool database predicted the structure of DTX_RING as a typical RING finger. However, the actual DTX_RING structure adopts a novel RING fold with a unique topology distinct from other RING fingers. We unveiled the position and the range of the DTX_RING active site at the atomic level. Artificial RING fingers (ARFs) are made by grafting active sites of the RING fingers onto cross‐brace structure motifs. Therefore, the present structural analysis could be useful for designing a novel ARF.
We are developing a robot that guides a user in a building to the destination room holding by the user's hand. We think that a robot and a human can adjust one's moving direction or position by communication with hands. However, conventional robot arms have two problems. First, the human is constrained within a range of the robot arm's movable scope and not easy to walk. Second, the robot arm is not safe enough when it collides with other people. Therefore, we propose a robot that has an expandable hand. It can follow the human flexibly by stretching/shrinking the hand held by the human. The hand is made with soft string, which ensures the safety. In this paper, we report the basic concept as well as the hardware configuration of the robot.
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