Chitosan oligomers form complexes with DNA in a structure-dependent manner. We conclude that the 24-mer, which has more desirable physical properties than UPC, is more attractive as a gene delivery system than the conventional high molecular weight chitosans.

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We report a new method to prepare giant liposome with the size of several tens micrometers, entrapping DNA molecule within the closed phospholipid membrane. The formation of such liposomes has been confirmed through the observation with fluorescence microscopy.