In order to identify the communication law of network public opinion in major public health emergency, a multifactor communication model based on multiagent modeling is proposed. Based on the SEIR model and NetLogo simulation analysis, the model integrates a variety of network public opinion communication characteristics and extends the existing single network public opinion communication model. Based on these studies, a network public opinion communication management system is designed and developed with Python tools. Case analysis and simulation results show that this model can better simulate the evolution trend of network public opinion communication in major public health emergency; the key communication channels of public opinion play an important role in the evolution of network public opinion, which can control and guide the network public opinion of major public health emergency from the three communication influencing factors of total number, initial number, and communication cycle. Communication cycle refers to the number of days in the process of network public opinion dissemination of major public health emergencies.
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