The oxidative coupling reaction of aldehydes with N,N'-disubstituted carbodiimides catalyzed by N-heterocyclic carbenes under aerobic conditions has been achieved. This reaction gives the corresponding N-acylurea derivatives in good to high yields. Various kinds of aldehydes including aliphatic ones and carbodiimides are applicable to this reaction.
Acylureas. -For the first time the oxidative coupling reaction of N,N-disubstituted carbodiimides with aldehydes catalyzed by a N-heterocyclic carbene (NHC) precatalyst under aerobic conditions is achieved. The coupling process tolerates a broad scope of substituents, but can be affected by steric influences. Unsymmetrically substituted carbodiimides (VII) react regioselectively. -(SOETA*, T.; TABATAKE, Y.; FUJINAMI, S.; UKAJI, Y.; Org. Lett. 15 (2013) 9, 2088-2091, http://dx.doi.org/10.1021/ol400672c ; Div. Mater. Sci., Grad. Sch. Nat. Sci. Technol., Kanazawa Univ., Kanazawa 920, Japan; Eng.) -H. Haber 34-041
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