The two-dimensional thin metal–organic frameworks (MOF) sheet has emerged as a promising hybrid material for applications in catalysis and optoelectronic devices. However, the small size and large thickness of an MOF sheet still pose barriers toward its potential applications. Herein, a micron-sized ultrathin MOF sheet is synthesized with the assistance of benzoic acid. Benzoic acid promoted the coordination of the porphyrin center with copper ions, reduced H-stacking and J-aggregation between the layers, and induced anisotropic growth of the MOF sheet. The results reveal the growth mechanism and provide a viable method for the synthesis of ultrathin MOF sheet. The as-prepared micron-sized ultrathin MOF sheet has good dispersion and high stability, which can ensure the long-term application properties of this material. The ultrathin thickness in combination with its micron size can make MOF as useful as graphene in practical applications. The synthesis of a micron-sized ultrathin MOF sheet similar to the thickness of graphene can pave the way for effective applications of two-dimensional MOF materials.

A novel porphyrin-based two-dimensional metal–organic framework (MOF) nanodisk with small size and few layers was prepared by coordination chelation between meso-tetra(4-carboxyphenyl)porphine ligand and Zn(ii) paddlewheel metal nodes.

Here, ferric oxide-loaded metal–organic framework (FeTCPP/Fe2O3 MOF) nanorice was designed and constructed by the liquid diffusion method. The introduction of iron metal nodes and the loading of Fe2O3 can effectively catalyze the Fenton reaction to produce hydroxyl radicals (•OH) and overcome the hypoxic environment of tumor tissue by generating oxygen. The monodispersity and porosity of the porphyrin photosensitizers in the MOF structure exposed more active sites, which promoted energy exchange between porphyrin molecules and oxygen molecules for photodynamic therapy (PDT) treatment. Therefore, the generated hydroxyl radicals and singlet oxygen (1O2) can synergistically act on tumor cells to achieve the purpose of improving tumor therapy. Then the erythrocyte membrane was camouflaged to enhance blood circulation and tissue residence time in the body, and finally, the targeted molecule AS1411 aptamer was modified to achieve the high enrichment of MOF photosensitizers on a tumor domain. As a result, the MOF nanorice camouflaged by the erythrocyte membrane can effectively reduce side effects and improve the therapeutic effect of PDT and chemo-dynamic therapy (CDT). The study not only improved the efficacy of PDT and CDT in essence from the MOF nanorice but also used the camouflage method to further concentrate FeTCPP/Fe2O3 on the tumor sites, achieving the goal of multiple gains. These results will provide theoretical and practical directions for the development of tumor-targeted MOF nanomaterials.