Background The role of nuclear magnetic resonance (NMR) metabolomics in the prevention of coronary heart disease (CHD) in postmenopausal women is unclear.Method 300 postmenopausal women, who were under moderate intensity statins, were enrolled in this study, of which, and 242 were assigned into CHD Group and the other 58 in non-CAHD Group. To seek the risk factors of CHD and the relationship among Gensini, PCSK9 and NMR results, Multivariate Logistic regression and Spearman correlation analysis were conducted, in all patients as well as the patients with CHD, diabetes mellitus (DM) and metabolic syndrome (MS). Results As the result of this study showed, Age was the main risk factor of CHD. Other risk factors including the particle of low-density lipoprotein (LDL)-6, LDL- triglyceride (TG) and LDL-free cholesterol (FC), while, ethanol and glycerol were the protective factors. In the Spearman correlation analyses section, lipoprotein contents of very-low-density lipoprotein (VLDL)-2 ~ VLDL-5, intermediate-density lipoprotein (IDL), LDL-1 and LDL-2 were proved to be positively related to Gensini, while the lipoprotein contents of apolipoprotein A1 (ApoA1), ApoA2 and high-density lipoprotein (HDL)-1 ~ HDL-4 were negatively correlated with Gensini. Conclusion In postmenopausal women, age was the main risk factor of CHD, besides, the NMR measured particle of LDL-6, LDL-TG and LDL-FC were also proved to be risk factors of CHD, while, ethanol and glycerol were the protective factors. The clinical significance of the NMR and the correlation among PCSK9, Gensini and NMR metabolomics need further studied.
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