The intramolecular nonbonded 1,5-type S···O interactions are
recognized in the crystalline structures
of the (acylimino)thiadiazoline derivatives
(1−3) as angiotensin II receptor antagonists.
The relative stability
of the nonbonded 1,5-type S···O interaction was investigated
using the X-ray crystallographic analyses and
the ab initio MO calculations (HF/3-21G*, 6-31G*, and 6-311+G**) of
the simplified model compounds (6,
7, and 9). The concept of mimic-fused
bicyclic heterocycles consisting of fairly stable nonbonded
S···O
interaction seems to be an efficient approach toward the design and
development of various drugs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.