Fibrosis is a common process of tissue repair response to multiple injuries in all chronic progressive diseases, which features with excessive deposition of extracellular matrix. Fibrosis can occur in all organs and tends to be nonreversible with the progress of the disease. Different cells types in different organs are involved in the occurrence and development of fibrosis, that is, hepatic stellate cells, pancreatic stellate cells, fibroblasts and myofibroblasts. Various types of programmed cell death, including apoptosis, autophagy, ferroptosis and necroptosis, are closely related to organ fibrosis. Among these programmed cell death types, necroptosis, an emerging regulated cell death type, is regarded as a huge potential target to ameliorate organ fibrosis. In this review, we summarize the role of necroptosis signalling in organ fibrosis and collate the small molecule compounds targeting necroptosis. In addition, we discuss the potential challenges, opportunities and open questions in using necroptosis signalling as a potential target for antifibrotic therapies.
We present a deep clustering-based MS data visualization strategy (MCnebula), integrated with the influential open-source automatic MS annotation platform SIRIUS and in vivo and in vitro methods, to screen and validate potential lead compounds from natural products.
Fibrosis is a common process of tissue repair response to multiple
injuries in all chronic progressive diseases, which featured with
excessive deposition of extracellular matrix. Actually fibrosis can
occur in all organs and tends to be nonreversible with the progresses of
the diseases. Different cells types in different organs are involved in
the occurrence and development of fibrosis, i.e. hepatic stellate cell,
pancreatic stellate cell, fibroblasts, myofibroblasts. Present studies
have shown that several programmed cell deaths including apoptosis,
autophagy, ferroptosis, and necroptosis were closely related to organ
fibrosis. Among these programmed cell deathes type, necroptosis, an
emerging regulated cell death type were regard as a huge potential
target to ameliorate organ fibrosis. In this review, we summarized the
role of necroptosis signaling in organ fibrosis, and collected the
present small molecule compounds targeting necroptosis. In addition, we
have discussed the potential challenges, opportunities and open
questions in using necroptosis signaling as a potential target for
antifibrotic therapies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.