1. EHD1 interacts with the CD44-ICD, promoting CD44 recycling and upregulating CD44 expression. 2. CD44 upregulation inhibits Hippo signalling activity, activating expression of downstream target genes involved in stemness and EMT. 3. SP1, as a downstream target of Hippo signalling, in turn transcriptionally activates EHD1 expression, finally forming an EHD1/CD44/Hippo/SP1 positive feedback loop that drives LUAD metastasis.
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