Confronting the challenge of the outbreak of COVID-19 should sharpen our focus on global drug access as a key issue in antiviral therapy testing. The testing and adoption of effective therapies for novel coronaviruses are hampered by the challenge of conducting controlled studies during a state of emergency. The access to direct antiviral drugs, such as ribavirin, that have an existing inventory and reliable supply chain may be a priority consideration for therapies developed for the 2019-nCoV infection outbreaks and any strain variants that may emerge. On the basis of the direct antiviral activity of ribavirin against 2019-nCoV in vitro and evidence for potency enhancement strategies developed during the prior SARS and MERS outbreaks, ribavirin may significantly impact our ability to end the lingering outbreaks in China and slow outbreaks in other countries. The apparent COVID-19 pandemic provides an opportunity to follow dosage guidelines for treatment with ribavirin, test new therapeutic concepts, and conduct controlled testing to apply the scientific rigor required to address the controversy around this mainstay of antiviral therapy.
Abstract:With the development of in-vehicle data collection devices, GPS trajectory has become a priority source to identify traffic congestion and understand the operational states of road network in recent years. This study aims to investigate the relationship between traffic congestion and built environment, including traffic-related factors and land use. Fuzzy C-means clustering was used to conduct an exhaustive study on the 24-hour congestion pattern of road segments in an urban area, so that the spatial autoregressive moving average model (SARMA) could be introduced to analyze the output from the clustering analysis to establish the relationship between built environment and the 24-hour congestion pattern. The clustering result classified the road segments into four congestion levels, while the regression explained the impact of 12 traffic-related factors and land-use factors on the road congestion pattern. The continuous congestion was found to mainly occur in the city center, and the factors, such as road type, bus station in the vicinity, ramp nearby, commercial land use, and so on, had large impacts on congestion formation. The Fuzzy C-means clustering is proposed to be combined with quantitative spatial regression, and the overall evaluation process will assist to assess the spatial-temporal levels of service regarding traffic from the congestion perspective.Keywords: Congestion pattern, taxi GPS data, fuzzy C-means clustering, spatiotemporal regression, built environment factor IntroductionIn urban road network, the recurrent or current congestion of a certain road segment may largely impact the local network and reduce travel efficiency. Consequently, it is important to identify the Compared with mobile phone data, floating car data, cargo transport vehicle record and navigation system, taxi GPS trace data is one of the easiest available sources for accurate travel route and travel time records for a wider area with more road details. Data mining based on taxi trip can be traced back to the 1970s (Goddard, 1970), which has been applied to a wide range of studies, mainly including activity-based and infrastructure-based fields. The activity-based studies mostly focus on driver behavior, supply-demand pattern, and traffic state analysis, while the infrastructure-based studies mainly focused on lanes channelization (Tang, Yang, Kan, & Li, 2015) and signal-timing estimation (Yu & Lu, 2016).From driver behavior perspective, Zhang, Qiu, Duan, Du, and Lu (2015) proposed a space-time visualization method to demonstrate taxi daily trajectories by GIS-T to recognize working time, operating range, and residence location without time division. Qing, Parfenov, and Kim (2015) compared direct extracted datas like travel distance, speed, demand, and supply mismatch of taxi trip between fair weather and extreme storm using Manhattan GPS data, and discovered the reduction in trip distance and supply of drives during the extreme storm. Meanwhile, Hwang, Wu and Jian (2006) used structural equation modeling technique...
Understanding individual daily activity patterns is essential for travel demand management and urban planning. This research introduces a new method to infer individuals' activities from their mobile phone traces. Using Metro Boston as an example, we develop an activity detection model with travel diary surveys to reveal the common laws governing individuals' activity participation, and apply the modeling results to mobile phone traces to extract the embedded activity information. The proposed approach enables us to spatially and temporally quantify, visualize, and examine urban activity landscapes in a metropolitan area and provides real-time decision support for the city. This study also demonstrates the potential value of combining new ''big data'' such as mobile phone traces and traditional travel surveys to improve transportation planning and urban planning and management.
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