On the basis of histopathological evaluations, it was shown that the harmful effect of inhalation of thinner in high concentrations to larynx mucosa is similar to the effect on other organs of the respiratory system.
A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Angiogenesis is a major factor in the development of solid tumors, such as endometrial cancer. Vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are important cytokines that stimulate angiogenesis in vivo. The aim of the current study was to determine VEGF and COX-2 expression in endometrial adenocarcinomas and to investigate the relationship between these parameters and clinicopathologic parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: Sections obtained from paraffin-embedded tissues in archive material of 23 patients who were diagnosed with endometrial carcinoma were retrospectively evaluated. VEGF and COX-2 expression levels in tumor cells and surrounding stroma on the tumor samples were determined by immunohistochemistry. R Re es su ul lt ts s: : VEGF and COX-2 were expressed both in the cytoplasm of tumor cells and in the stromal cells, but in a lower degree. There was a significant positive correlation between VEGF expressions of cancer cells and the stroma (r= 0.705, p< 0.01). A negative correlation was found between histological grade of the tumor and VEGF expression of cancer cells (r= -0.622, p= 0.002). A negative correlation was determined between myometrial invasion of the tumor and COX-2 expression of cancer cells (r= -0.441, p= 0.035). C Co on nc cl lu us si io on n: : Both VEGF and COX-2 were expressed by both tumor cells and stromal cells in endometrial cancer. While VEGF expression showed a negative correlation with the tumor grade, COX-2 expression exhibited a negative correlation with the myometrial invasion of the tumor. No correlation was determined between their expressions and other clinicopathologic prognostic parameters.K Ke ey y W Wo or rd ds s: : Vascular endothelial growth factor A; cyclooxygenase-2; endometrial neoplasms; neovascularization, pathologic; immunohistochemistry Ö ÖZ ZE ET T A Am ma aç ç: : Anjiyogenez, endometriyal kanser gibi solid tümörlerin gelişiminde önemli bir faktördür. Vasküler endotelyal büyüme faktörü (VEGF) ve siklooksijenaz-2 (COX-2) in vivo ortamda anjiyogenezi uyaran önemli sitokinlerdir. Bu çalışmanın amacı, endometriyal adenokarsinomlarda VEGF ve COX-2 sunumlarının belirlenmesi ve bu parametrelerin klinikopatolojik parametrelerle ilişkisinin araştırılmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Endometriyal karsinom tanısı almış 23 hastaya ait arşiv materyalindeki parafine gömülü dokulardan alınan kesitler geriye dönük olarak değerlendirildi. Tümör örneklerinde tümör hücreleri ve çevreleyen stromal dokuda VEGF ve COX-2 sunum dü-zeyleri immünohistokimyasal olarak saptandı. B Bu ul lg gu ul la ar r: : VEGF ve COX-2'nin hem tümör hücrele-rinin sitoplazmasında hem de daha düşük derecede olmak üzere tümör stromasındaki hücrelerde sunulduğu görüldü. Kanser hücreleri ve stroma arasında VEGF sunumları açısından anlamlı bir pozitif ilişki vardı (r= 0,705, p< 0,01). Tümörün histolojik derecesi ve kanser hücrelerinin VEGF sunumu arasında negatif bir il...
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