As acquired immunodeficiency syndrome (AIDS) caused by HIV-1 (human immunodeficiency virus type 1) has been in the top 10 leading causes of death for recent years, there have been many promising treatment discovered. One of the treatments is by taking non-nucleoside reverse transcriptase inhibitors (NNRTI) to suppress the activity of the HIV-1. The binding affinity of NNRTI to the reverse transcriptase (RT) of HIV-1 is an important factor determining the efficiency of the drug performance. The HIV-1 RT immobilized AlGaN/GaN high electron mobility transistors (HEMTs) were used to find the dissociation constant of NNRTIs. Comparing to conventional drug analyzing, HEMTs assisting experiments are much faster in processing time and lower cost.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.