Objectives Glucose-6-phosphate dehydrogenase (G6PD) has role in the Embden Meyerhof road. Any loss of its function causes NADPH to cease, leaving erythrocytes susceptible to oxidative damage resulting in acute hemolytic anemia attacks secondary to drugs or infection and favism. Because of X-linked recessive inheritance males are mainly affected. Being heterozygous, females have less severe clinical presentation. Case presentation G6PD deficiency was suspected in a six-year-old girl from an Iraqi family with a history of yellowing of skin and darkening of urine after eating broad beans. Besides the patient, G6PD levels were found low in the father and in two sisters who showed no symptoms. The father was found hemizygous and the three sisters were found heterozygous for NM_000402.4c.1093G>A(p.A365T)(6.Ala365Thr) mutation while the mother was normal. Conclusions G6PD enzyme deficiency can be seen in both genders, and it may be presented with different clinical manifestations even within the people having the same mutation.
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Introduction: We aim to examine the role of Platelet to lymphocyte ratio (PLR) and Platelet to Lymphocyte and monocyte ratio (PLT/LY+MO) values in Respiratory Syncytial Virus (RSV) infection. Methodology: Complete blood counts and RSV Antigen test results of 76 patients, between the age of 0-12 were investigated retrospectively. PLR values are calculated using Platelet Count / Lymphocyte Count formula, whereas PLMR values are calculated using Platelet Count / Lymphocyte Count + Monocyte Count. Results: Out of 76, 32 patients were diagnosed as RSV infected. Lymphocyte and monocyte percentage and platelet count were significantly higher in RSV positive group. Monocyte percentage in lower respiratory tract RSV infection was significantly lower compared to upper respiratory tract RSV infection. Conclusions: Our study revealed that these blood parameters may be an important clue for the clinician for RSV infection and also play a role as a guide before advanced techniques.
Aim: Panic values are laboratory test results that indicate that the patient may be in a life-threatening condition if urgent action is not taken. Each medical laboratory should determine their panic values and also they have to report and document the results. Chronic myeloproliferative neoplasms (MPN), including malign diseases such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia, is a malignant and clonal disease of hematopoietic tissue. In 2016, World Health Organization (WHO) updated the criteria of classification for hematopoietic and lymphoid tissue tumors. The aim of this study is to compare the panic value reports of our laboratory with the number of tests that exceed the limit values for chronic MPNs determined according to the new WHO criteria. Materials and Method: In the study, the results of complete blood count of 58223 patients over the age of 15 were evaluated. Hemoglobin, hematocrit, platelet and leukocyte counts were evaluated and compared according to reported the panic values of our laboratory and the WHO criteria for chronic MPN. Results: When the hemoglobin values are evaluated due to currently used panic values instead of WHO criteria, the necessity of bone marrow examination is overlooked and 1.13% of women and 8.90% of men could not be followed in terms of chronic MPN. Also, the hematocrit values of 9.59 % of women and 8.52% men could not be informative. The hemoglobin values in 0.68% of women and in 1.74% of men; the hematocrit values in 0.94 % of women and in 0.38% of men could not be taken as a warning for chronic MPN without performing marrow examination. For platelet and leukocyte counts the rates are 2.20% and 24.78%, respectively. Conclusion: In order to provide early information in terms of chronic MPN, panic values should be reviewed and rearranged according criteria in the 2016 WHO guideline.
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