ABSTRACT. Corticobasal degeneration (CBD) is a sporadic tauopathy that presents with a varied combination of motor, cognitive, and behavioral features, making its diagnosis difficult. CBD has high morbidity and poor prognosis, with no effective therapy at present. We searched the PubMed/MEDLINE database for articles published from 1990 to 2019, using the keywords “corticobasal degeneration” AND “treatment.” The PRISMA method was adopted. Retrieved articles were characterized as having one of two methodological approaches: (1) studies aimed at primary tauopathy treatment and (2) symptomatic management. Review articles (based on CBD expert groups), case reports, case series, and pilot clinical trials were selected. Few attempts have been made to study drug options and drug efficacy in CBD systematically, and an effective treatment is not yet available. Treatment is symptomatic and based on similarity with other diseases due to the scarcity of studies specifically addressing CBD. CBD seems not to spark interest in more clinical trials for its low prevalence and reliability in clinical diagnosis.
France and Germany) cross-sectional study that obtained patient consent/approval. Average treatment effects (ATEs) for 1113 patients (156 natalizumab, 711 platform, 246 oral) were estimated and adjusted utilizing a propensity score generated from age, gender, EDSS score at current treatment initiation, line-of-therapy, BMI, duration of current treatment, time since MS diagnosis, and number of comorbid conditions. Physician-reported relapses in the previous 12 months and work productivity were compared across treatments. Results: Relapse and WPAI data were available for 934 (122 natalizumab, 617 platform, 195 oral) and 222 (34 natalizumab, 137 platform, 51 oral) patients, respectively. Natalizumab patients suffered fewer relapses than platform (ATE = − 0.21 vs. 0.48, p = 0.020) and oral therapy patients (ATE = −0.14 vs. 0.45, p = 0.075). Patients receiving natalizumab reported significantly less presenteeism, i.e., attending work while sick) than those receiving platform (ATE = −10.16% vs. 19.26%, p = 0.001) or oral therapies (ATE = −8.28% vs. 22.65%, p = 0.0018). Treatment was not associated with less overall work impairment. Conclusion: Treatment with natalizumab compared to platform or oral therapies was associated with a lower relapse rate and a significant reduction in impairment at work or presenteeism.Sponsored by Biogen.
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