With their unique biological effects on tumor microenvironment, catabolites of nanoparticles can make a significant difference for tumor suppression. We report a facile synthesis method of ultrasmall calcium peroxide nanoparticles and demonstrate their rapid decomposition in tumor region. This can trigger a destructive calcium overload process in tumor cells, lead to cell death, and further tissue calcification, which also allows for medical imaging.

A series of alkylpyrimidine-4,6-diol derivatives were designed and synthesized as novel GRP84 agonists based on a high-throughput screening (HTS) hit 1. 6-Nonylpyridine-2,4-diol was identified as the most potent agonist of GPR84 reported so far, with an EC50 of 0.189 nM. These novel GPR84 agonists will provide valuable tools for the study of the physiological functions of GPR84.

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