Background: The coronavirus disease-19 (COVID-19) outbreak on December 2019.The present study was aimed to explore the therapeutic effects and the network pharmacology mechanism of Chinese herbs in COVID-19 patients.Methods: In this retrospective study, demographic, clinical signs, radiography, and laboratory of 78 patients were analysis from patients' medical records. Network pharmacology was applied to characterize the action mechanism of herbs decoction. Results: Of all patients were imported cases with familial aggregation. Survival analysis showed that the proportion of cough (χ2 =3.864, P=0.049) and fever (χ2 =5.549, P=0.018) in TCM group declined faster than control group. There was a significant radiographic lesions remission difference between groups (χ2 =7.666, P=0.006). After adjusted by baseline data, the changes of Lymphocytes, ALT and LDH were greater in TCM group (P=0.023, 0.005, 0.015, respectively). A total of 1852 ingredients in 13 herbs were obtained, among which, the ingredients-target network included 168 compounds and 189 targets, 38 GO terms and 63 pathways were found in enrichment analysis. Conclusion: The therapeutic effect of Chinese herbs was amelioration of cough and fever, facilitated the absorption of inflammatory infiltrates seen in the lungs, and increased the number of lymphocytes, protection of liver function via the mechanism of inhibition of coronavirus attack organs and immune cells directly. Molecular mechanisms need to be further validate in vitro and vivo.
UNSTRUCTURED Introduction: The emergence of coronaviruses, including SRAS-CoV and SARS-CoV-2, is thought to be a pandemic threat to human beings and has aroused considerable academic concern worldwide. The aim of this study was to map research productivity and explore the characteristics of global literatures from SARS to the emerging COVID-19. Methods: Thomson Reuters Web of Science was searched to retrieve 12632 articles related to coronavirus between 1991 and 2020, 2701 articles concerning SARS dated from 2002 to 2020 March, 566 articles corresponded to COVID-19 published by 2020 March. The parameters using VOSviewer and CiteSpaceV. Results: In SARS research field, the most prolific country was China (1115 articles; 41.2%), followed by USA (816; 30.2%). The top 3 most published institutes were University of Hong Kong, Chinese Academy of Sciences, Chinese University of Hong Kong. The authors with greatest numbers of publications was Yuen KY (78 articles), followed by Peiris JSM (73 articles) and Chan PKS (65 articles). “identification”, “infection”, “outbreak” and “spike protein” were found to be among the most frequently used topics. While articles relevant to COVID-19 were most published in China (43.29%) and USA (17.67%), with Fudan University being the most productive (4.06%). LANCET was the most exploited journal (IF 59.102). Besides, the most highly cited publications and co-citation reference were also unmasked from this bibliometric analysis. Conclusions: The findings will provide valuable information for current researchers to learn from the study experience and find effective strategies for COVID-19 control as soon as possible.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.