In this paper, a novel adaptive second-order sliding mode (2-SM) control approach, based on online zero-crossing detection, was proposed to solve the problems of the chattering and fixed control gain for buck converters with multi-disturbances. In modeling, the possible parameter perturbations and external disturbances of the converter system were contained. Instead of the traditional first-order sliding mode (1-SM), the twisting algorithm with 2-SM was adopted for the controller design, which could overcome the chattering problem and realize control continuity. Meanwhile, a novel adaptive mechanism was introduced to replace the conventional fixed control gain by time-varying control gain, the idea of which is to calculate the number of the zero-crossing points of the sliding surface online. As a result, the control magnitude of the improved controller could be reduced to a minimal admissible level, and the steady error of the output voltage could converge to the expected value. Furthermore, the robust stability of the converter system with multi-disturbances wads investigated. Comparative simulations and experiments validated the advantages of this paper as offering better robustness and control performance.