BACKGROUND AND PURPOSE:Human papillomavirus-associated oropharyngeal squamous cell carcinoma is increasing in prevalence and typically occurs in younger patients than human papillomavirus-negative squamous cell carcinoma. While imaging features of human papillomavirus-positive versus human papillomavirus-negative squamous cell carcinoma nodal metastases have been described, characteristics distinguishing human papillomavirus-positive from human papillomavirus-negative primary squamous cell carcinomas have not been well established. The purpose of this project was to evaluate the use of texture features to distinguish human papillomaviruspositive and human papillomavirus-negative primary oropharyngeal squamous cell carcinoma.
Texture analysis demonstrated significant differences between HPV and HPV non-OPCs on computed tomography images, which may have a potential to prove morphologic feature differences among HPV-related tumors.
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