Multidrug-resistant (MDR) bacterial infections are a
severe threat
to public health owing to their high risk of fatality. Noticeably,
the premature degradation and undeveloped imaging ability of antibiotics
still remain challenging. Herein, a selenium nanosystem in response
to a bacteria-infected microenvironment is proposed as an antibiotic
substitute to detect and inhibit methicillin-resistant Staphylococcus aureus (MRSA) with a combined strategy.
Using natural red blood cell membrane (RBCM) and bacteria-responsive
gelatin nanoparticles (GNPs), the Ru–Se@GNP-RBCM nanosystem
was constructed for effective delivery of Ru-complex-modified selenium
nanoparticles (Ru–Se NPs). Taking advantage of natural RBCM,
the immune system clearance was reduced and exotoxins were neutralized
efficiently. GNPs could be degraded by gelatinase in pathogen-infected
areas in situ; therefore, Ru–Se NPs were released
to destroy the bacteria cells. Ru–Se NPs with intense fluorescence
imaging capability could accurately monitor the infection treatment
process. Moreover, excellent in vivo bacteria elimination
and a facilitated wound healing process were confirmed by two kinds
of MRSA-infected mice models. Overall, the above advantages proved
that the prepared nanosystem is a promising antibiotic alternative
to combat the ever-threatening multidrug-resistant bacteria.
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