β2-microglobulin is a single-chain, low molecular weight (MW=11.8 kDA) polypeptide [1,2] and has similar structure to the CH 3 domain of the immunoglobulin molecule [3]. β2-microglobulin forms the invariant light chain portion of major histocompatibility complex (MHC) class I molecules [4][5][6], which can be found on the membrane of all nucleated cells [7]. Thus, cellular membrane turnover is the main source of serum β2-microglobulin [3]. Because of its small size, β2-microglo- Objective: After filtration through the glomeruli of the kidney, β2-microglobulin is reabsorbed by the renal proximal tubules. Increase in urinary β2-microglobulin indicates tubular dysfunction, and measurement of β2-microglobulin in urine sediment is useful to determine the source of kidney injury. CD133 has recently been characterized as a progenitor cell marker in the kidney, detecting injured epithelial cells in the proximal tubules. This study was designed to evaluate the correlation of increase in urinary β2-microglobulin and CD133 staining in patients with tubular injury. Urinary β2-Microglobulin is a Sensitive Indicator for Renal Tubular InjuryAbstract
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.