Osteoporosis is a group of diseases in which the bone mass is significantly reduced, predisposing patients to spontaneous bone fragility and bone fractures. It has been reported that more than 70 million people worldwide are affected by this life-threatening problem. 1 The integrity and structure of the skeleton are precisely regulated by osteoclastogenesis (mediated by osteoclasts) coupled with osteogenesis (mediated by osteoblasts). 2,3 However, excessive bone resorption by osteoclasts destabilizes this balance, ultimately causing chronic lytic diseases such as osteoporosis. 4 Therefore, identification of agents that can modulate the formation and activity of osteoclasts is important for the treatment of osteoporosis. Osteoclasts, if not exclusive, are the primary bone-resorbing cells. During the process of osteoclastogenesis, osteoclasts degrade the bone matrix by producing and secreting cathepsin K (CtsK) and tartrate-resistant acid phosphatase
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