carrier, equipping with satisfactory biodegradability and special surface structure for protein drug delivery, is of great significance for enzyme-mediated therapeutic applications. [16,17] Nanocarriers that can afford reduced toxicity, favorable biocompatibility, and high drug loading efficiency are important to cope with the critical issues in drug delivery for diseases treatment. [18][19][20] As a forgeable material, gallium indium liquid metal (LM) has received increasing attention owing to its favorable biocompatibility and low nonspecificity toxicity. [21][22][23][24][25] With the property of degradation in a mildly acidic environment, a transformable LM nanomedicine was designed to achieve enhanced antitumor therapy. [26,27] Benefitting from the good transformable property of LM, a light-fueled transformer was constructed for effective endosomal escapefacilitated cargo delivery. [28] Similar to gold or silver nanoparticles, LM nanoparticles exhibit excellent photothermal conversion property that is superior to many traditional photothermal conversion agents (PTAs), which makes LM a potential PTA for cancer therapy. [23,31,43] More interestingly, it was found that thorns would grow on both sides of LM when LM transformed from spherical to cylindrical, resulting in a rough surface for biomolecules adhesion. [29,30] The specific surface physicochemical and transformable properties make LM an appropriate carrier for macromolecular drug delivery. [31] As a potential strategy for tumor treatment, chemodynamic therapy (CDT) has received increasing focuses in recent years because of its effective way of converting hydrogen peroxide (H 2 O 2 ) into lethal hydroxyl radicals (•OH). [32][33][34] However, the monotherapy of CDT showed limited antitumor efficacy because of the insufficient H 2 O 2 level in tumor cells. [35,36] Among various H 2 O 2 supply strategies, enzymes-mediated consumption of nutrients and generation of H 2 O 2 , which can meet the requirements of CDT, has attracted increasing interest. [37,38] As a natural biocatalyst, plasma amine oxidase (PAO) can facilitate the formation of virulent aldehydes and H 2 O 2 by initiating the oxidative deamination of polyamines, [39,40] including spermine (Spm) and spermidine (Spd) that are attractive targets for therapeutic intervention since these highly charged molecules are essential for eukaryotic cell growth. [41,42] Thus, the method of converting of polyamines into H 2 O 2 for enhanced CDT is a highly desirable strategy for tumor therapy.