Highlights d The four types of CD3 signaling chains of TCR have functional diversity d CD3ε recruits Csk and p85 via its mono-phosphorylated ITAM and BRS motif respectively d Incorporation of CD3ε into 28Z CAR alters signaling to promote antitumor function d E28Z CAR-T cells have reduced cytokine production but enhanced persistence

2D perovskites have attracted extensive attention due to their excellent stability compared with 3D perovskites. However, the intrinsic hydrophilicity of introduced alkylammonium salts effects the humidity stability of 2D/3D perovskites. Devices based on longer chain alkylammonium salts show improvement in hydrophobicity but lower efficiency due to the poorer charge transport among various layers. To solve this issue, two hydrophobic short-chain alkylammonium salts with halogen functional groups (2-chloroethylamine, CEA + and 2-bromoethylamine, BEA + ) are introduced into (Cs 0.1 FA 0.9 )Pb(I 0.9 Br 0.1 ) 3 3D perovskites to form 2D/3D perovskite structure, which achieve high-quality perovskite films with better crystallization and morphology. The optimal 2D/3D perovskite solar cells (PSCs) with 5% CEA + display a power conversion efficiency (PCE) as high as 20.08% under 1 sun irradiation. Because of the notable hydrophobicity of alkylammonium cations with halogen functional groups and the formed 2D/3D perovskite structure, the optimal PSCs exhibit superior moisture resistance and retain 92% initial PCE after aging at 50 ± 5% relative humidity for 2400 h. This work opens up a new direction for the design of new-type 2D/3D PSCs with improved performance by employing proper alkylammonium salts with different functional groups.