Autoimmune diseases are usually accompanied by tissue injury caused by autoantigen-specific T-cells. KV1.3 channels participate in modulating calcium signaling to induce T-cell proliferation, immune activation and cytokine production. Effector memory T (TEM)-cells, which play major roles in many autoimmune diseases, are controlled by blocking KV1.3 channels on the membrane. Toxins derived from animal venoms have been found to selectively target a variety of ion channels, including KV1.3. By blocking the KV1.3 channel, these toxins are able to suppress the activation and proliferation of TEM cells and may improve TEM cell-mediated autoimmune diseases, such as multiple sclerosis and type I diabetes mellitus.
Accurately predicting the carbon price sequence is important and necessary for promoting the development of China’s national carbon trading market. In this paper, a multiscale ensemble forecasting model that is based on ensemble empirical mode decomposition (EEMD-ADD) is proposed to predict the carbon price sequence. First, the ensemble empirical mode decomposition (EEMD) is applied to decompose a carbon price sequence, SZA2013, into several intrinsic mode functions (IMFs) and one residual. Second, the IMFs and the residual are restructured via a fine-to-coarse reconstruction algorithm to generate three stationary and regular frequency components that high frequency component, low frequency component, and trend component. The fluctuation of each component can effectively reveal the factors that influence market operation. Third, extreme learning machine (ELM) is applied to forecast the trend component, support vector machine (SVM) is applied to forecast the low frequency component and the high frequency component is predicted via PSO-ELM, which means extreme learning machine whose input weights and bias threshold were optimized by particle swarm optimization. Then, the predicted values are combined to form a final predicted value. Finally, using the relevant error-type and trend-type performance indexes, the proposed multiscale ensemble forecasting model is shown to be more robust and accurate than the single format models. Three additional emission allowances from the Shenzhen Emissions Exchange are used to validate the model. The empirical results indicate that the established model is effective, efficient, and practical in terms of its statistical measures and prediction performance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.