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The effect of rutin (RT) on the expression of PPARγ in the skeletal muscle of db/db mice has been investigated. Thirty db/db mice were randomized into 5 equal groups: model control group (MCG), positive control group 30 mg/kg pioglitazone hydrochloride (PCG), low-dose rutin group 50 mg/kg (LRT), middle-dose rutin group 100 mg/kg (MRT), high-dose rutin group 200 mg/kg (HRT), and 6 other db/m mice were used as the normal control (NC). The expression of PPARγ mRNA and protein in the skeletal muscle was determined by real-time quantitative PCR and Western Blot, respectively. Treatment with HRT resulted in significant decreases in the plasma levels of glucose and lipids (p < 0.001). Compared to the MCG, the expression of PPARγ mRNA and protein of the skeletal muscle was significantly increased in the HRT and PCG groups (p < 0.001 and p < 0.05, respectively). Rutin can increase the expression of PPARγ in skeletal muscles of db/db mice.