Single-layer transition-metal dichalcogenides (TMDs) receive significant attention due to their intriguing physical properties for both fundamental research and potential applications in electronics, optoelectronics, spintronics, catalysis, and so on. Here, we demonstrate the epitaxial growth of high-quality single-crystal, monolayer platinum diselenide (PtSe2), a new member of the layered TMDs family, by a single step of direct selenization of a Pt(111) substrate. A combination of atomic-resolution experimental characterizations and first-principle theoretic calculations reveals the atomic structure of the monolayer PtSe2/Pt(111). Angle-resolved photoemission spectroscopy measurements confirm for the first time the semiconducting electronic structure of monolayer PtSe2 (in contrast to its semimetallic bulk counterpart). The photocatalytic activity of monolayer PtSe2 film is evaluated by a methylene-blue photodegradation experiment, demonstrating its practical application as a promising photocatalyst. Moreover, circular polarization calculations predict that monolayer PtSe2 has also potential applications in valleytronics.

Background-Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation of cardiomyocyte death. However, the signature of miRNA expression and possible roles of miRNA in the ischemic heart have been less well studied. Methods and Results-We performed miRNA arrays to detect the expression pattern of miRNAs in murine hearts subjected to ischemia/reperfusion (I/R) in vivo and ex vivo. Surprisingly, we found that only miR-320 expression was significantly decreased in the hearts on I/R in vivo and ex vivo. This was further confirmed by TaqMan real-time polymerase chain reaction. Gain-of-function and loss-of-function approaches were employed in cultured adult rat cardiomyocytes to investigate the functional roles of miR-320. Overexpression of miR-320 enhanced cardiomyocyte death and apoptosis, whereas knockdown was cytoprotective, on simulated I/R. Furthermore, transgenic mice with cardiac-specific overexpression of miR-320 revealed an increased extent of apoptosis and infarction size in the hearts on I/R in vivo and ex vivo relative to the wild-type controls. Conversely, in vivo treatment with antagomir-320 reduced infarction size relative to the administration of mutant antagomir-320 and saline controls. Using TargetScan software and proteomic analysis, we identified heat-shock protein 20 (Hsp20), a known cardioprotective protein, as an important candidate target for miR-320. This was validated experimentally by utilizing a luciferase/GFP reporter activity assay and examining the expression of Hsp20 on miR-320 overexpression and knockdown in cardiomyocytes. Conclusions-Our data demonstrate that miR-320 is involved in the regulation of I/R-induced cardiac injury and dysfunction via antithetical regulation of Hsp20. Thus, miR-320 may constitute a new therapeutic target for ischemic heart diseases. Key Words: apoptosis Ⅲ ischemia Ⅲ microRNA Ⅲ myocardial infarction Ⅲ reperfusion M ore than 1 million Americans suffer from myocardial infarction every year. 1 Both human autopsy data and evidence from rodent models of myocardial infarction indicate that most cell death happens by apoptosis during the initial 2 to 4 hours after coronary occlusion. 2,3 Clinical treatment of myocardial infarction by thrombolytic therapy and revascularization by percutaneous coronary intervention or coronary artery bypass graft surgery are effective. 1,3 However, given the health, economic, and personal burden caused by ischemic heart disease, research into additional treatment modalities is imperative. Furthermore, the molecular mechanisms that regulate gene expression during myocardial ischemia/reperfusion (I/R) are still not completely understood. Clinical Perspective on p 2366MicroRNAs (miRNAs) are a class of endogenous nonprotein-coding RNAs comprising Ϸ22 nucleotides. 4 -6 They regulate gene expression via RNA-induced silencing complexes, targeting them to mRNAs where they inhibit translation or direct destructive cleavage. 4 -6 Increasing evidence indicates the importa...

The oxygen evolution reaction (OER) is the bottleneck that limits the energy efficiency of water-splitting. The process involves four electrons’ transfer and the generation of triplet state O2 from singlet state species (OH- or H2O). Recently, explicit spin selection was described as a possible way to promote OER in alkaline conditions, but the specific spin-polarized kinetics remains unclear. Here, we report that by using ferromagnetic ordered catalysts as the spin polarizer for spin selection under a constant magnetic field, the OER can be enhanced. However, it does not applicable to non-ferromagnetic catalysts. We found that the spin polarization occurs at the first electron transfer step in OER, where coherent spin exchange happens between the ferromagnetic catalyst and the adsorbed oxygen species with fast kinetics, under the principle of spin angular momentum conservation. In the next three electron transfer steps, as the adsorbed O species adopt fixed spin direction, the OER electrons need to follow the Hund rule and Pauling exclusion principle, thus to carry out spin polarization spontaneously and finally lead to the generation of triplet state O2. Here, we showcase spin-polarized kinetics of oxygen evolution reaction, which gives references in the understanding and design of spin-dependent catalysts.

LaCoO 3 is an active, stable catalyst in alkaline solution for oxygen evolution reaction (OER). With lower cost, it is a potential alternative to precious metal oxides like IrO 2 and RuO 2 in water electrolysis. However, room still remains for improving its activity according to recent understandings of OER on perovskite oxides. In this work, Fe substitution has been introduced in LaCoO 3 to boost its OER performance. Density function theory (DFT) calculation verified that the enhanced performance originates from the enhanced Co 3d-O 2p covalency with 10 at% Fe substitution in LaCoO 3 . Both DFT calculations and Superconducting Quantum Design (SQUID) magnetometer (MPMS-XL) showed a Co 3+ spin state transition from generally low spin state (LS: t 2g 6 e g 0 , S = 0) to a higher spin state with the effect of 10 at% Fe substitution. X-ray absorption near-edge structure (XANES) supports DFT calculations on an insulator to half-metal transition with 10 at% Fe substitution, induced by spin state transition. The half-metallic LaCo 0.9 Fe 0.1 O 3 possesses increased overlap between Co 3d and O 2p states, which results in enhanced covalency and promoted OER performance. This finding enlightens a new way of tuning the metal−oxygen covalency in oxide catalysts for OER.

Kitaev interactions underlying a quantum spin liquid have long been sought, but experimental data from which their strengths can be determined directly, are still lacking. Here, by carrying out inelastic neutron scattering measurements on high-quality single crystals of α-RuCl_{3}, we observe spin-wave spectra with a gap of ∼2  meV around the M point of the two-dimensional Brillouin zone. We derive an effective-spin model in the strong-coupling limit based on energy bands obtained from first-principles calculations, and find that the anisotropic Kitaev interaction K term and the isotropic antiferromagnetic off-diagonal exchange interaction Γ term are significantly larger than the Heisenberg exchange coupling J term. Our experimental data can be well fit using an effective-spin model with K=-6.8  meV and Γ=9.5  meV. These results demonstrate explicitly that Kitaev physics is realized in real materials.

The development of efficient electrocatalysts that lower the overpotential of oxygen evolution reaction (OER) is of great importance in improving the overall efficiency of hydrogen fuel production by water electrolysis. [1] Commercially, precious metal oxides catalysts such as IrO 2 are used. [2] However, their elemental scarcity and high cost have triggered a search for cost-effective OER electrocatalysts such as 3d transition metal oxides. Among them, families such as the perovskite ABO 3 and the spinel AB 2 O 4 ones have attracted great attention due to their tunable structural/elemental properties allowed by A and B site cation substitution. [3,4] Perovskite ABO 3 oxides have a simple structure with rare-earth or alkaline earth element occupying cuboctahedral A-site while the B-site transition metal (TM) sites in an octahedral environment. [3] Spinel oxides, however, can be either normal or inverse structure depending on the relative occupancy of divalent and trivalent cations in the octahedral and Developing highly active electrocatalysts for oxygen evolution reaction (OER) is critical for the effectiveness of water splitting. Low-cost spinel oxides have attracted increasing interest as alternatives to noble metalbased OER catalysts. A rational design of spinel catalysts can be guided by studying the structural/elemental properties that determine the reaction mechanism and activity. Here, using density functional theory (DFT) calculations, it is found that the relative position of O p-band and M Oh (Co and Ni in octahedron) d-band center in ZnCo 2−x Ni x O 4 (x = 0-2) correlates with its stability as well as the possibility for lattice oxygen to participate in OER. Therefore, it is testified by synthesizing ZnCo 2−x Ni x O 4 spinel oxides, investigating their OER performance and surface evolution. Stable ZnCo 2−x Ni x O 4 (x = 0-0.4) follows adsorbate evolving mechanism under OER conditions. Lattice oxygen participates in the OER of metastable ZnCo 2−x Ni x O 4 (x = 0.6, 0.8) which gives rise to continuously formed oxyhydroxide as surface-active species and consequently enhances activity. ZnCo 1.2 Ni 0.8 O 4 exhibits performance superior to the benchmarked IrO 2 . This work illuminates the design of highly active metastable spinel electrocatalysts through the prediction of the reaction mechanism and OER activity by determining the relative positions of the O p-band and the M Oh d-band center.

Transition metal dichalcogenide MoTe2 is an important candidate for realizing the newly predicted type-II Weyl fermions, for which the breaking of the inversion symmetry is a prerequisite. Here we present direct spectroscopic evidence for the inversion symmetry breaking in the low-temperature phase of MoTe2 by systematic Raman experiments and first-principles calculations. We identify five lattice vibrational modes that are Raman-active only in the low-temperature noncentrosymmetric structure. A hysteresis is also observed in the peak intensity of inversion symmetry-activated Raman modes, confirming a temperature-induced structural phase transition with a concomitant change in the inversion symmetry. Our results provide definitive evidence for the low-temperature noncentrosymmetric Td phase from vibrational spectroscopy, and suggest MoTe2 as an ideal candidate for investigating the temperature-induced topological phase transition.

Cobalt spinel oxides are ac lass of promising transition metal (TM) oxides for catalyzing oxygen evolution reaction (OER). Their catalytic activity depends on the electronic structure.I naspinel oxide lattice,e acho xygen anion is shared amongst its four nearest transition metal cations,ofwhich one is located within the tetrahedral interstices and the remaining three cations are in the octahedral interstices. This work uncovered the influence of oxygen anion charge distribution on the electronic structure of the redox-active building blockC o ÀO. The charge of oxygen anion tends to shift toward the octahedral-occupied Co instead of tetrahedraloccupied Co,w hich hence produces strong orbital interaction between octahedral Co and O. Thus,t he OER activity can be promoted by pushing more Co into the octahedral site or shifting the oxygen charge towards the redox-active metal center in CoO 6 octahedra.The clean-burning hydrogen fuel, if produced by electrochemical water splitting, would revolutionize the global energy infrastructure.T he major limitation of water splitting is the sluggish oxygen evolution reaction (OER) at the anode. [1] To date,the most efficient OER electrocatalysts are made from noble metal ruthenium or iridium. In order to meet the broader goal of sustainability,e xploring earthabundant transition metal (TM) oxide catalysts have been prioritized. [1b, 2] Better understanding of the OER reaction on TM oxides is necessary to this end. It has been found that the surface redox-active centers in TM oxides play ak ey role in oxygen electrocatalysis. [3] Thec onventional perception of oxygen evolution regards the redox-active metallic center as the active site and it is the redox ability of TM that mediates the transition of [M n+ ÀOH ad ]/[M n+1 ÀO ad ]d uring OER. [3,4] However,t he redox of late transition metal oxides (e.g., Coand Ni-based) could involve both the transition metal and oxygen ligand due to the increased orbital hybridization between TM 3d and O2 p. [2,5] Earlier reports had demonstrated that the energy in TM 3d orbital cannot be treated in isolation from O2pwhen there is significant overlap between TM 3d and O2 p. Recent studies on oxygen-deficient perovskite oxides reveal that the oxygen anion could also act as the redox partner in OER. [6] Direct evidence for lattice oxygen participated OER using in situ 18 Oi sotope labelling mass spectrometry has been given by Alexis et al. [6b] Thefact that the oxygen anion can also act as the redox-active center emphasizes the importance of considering TM À Obond as the redox-active building block. More recently,t he covalent character (covalency) of TM Bs ite ÀOb ond (TM B the TM in B site) has been proposed to be adominating factor in OER on perovskite oxides. [6b, 7] TheA -site rare-earth metals (low in electronegativity) tend to form an ionic bond with Oa nd weaken the influence of M A -O block on OER. Spinel oxides, ah uge crystal family for oxygen electrocatalysis, [2,4,8] require more complex analysis because the tetrahedral and octahe...