Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits their antibacterial properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. Cu SASs/NPC have stronger peroxidase-like catalytic activity, glutathione (GSH)-depleting function, and photothermal property compared with non-Cu-doped NPC, indicating that Cu doping significantly improves the catalytic performance of nanozymes. Cu SASs/NPC can effectively induce peroxidase-like activity in the presence of H 2 O 2 , thereby generating a large amount of hydroxyl radicals (•OH), which have a certain killing effect on bacteria and make bacteria more susceptible to temperature. The introduction of near-infrared (NIR) light can generate hyperthermia to fight bacteria, and enhance the peroxidase-like catalytic activity, thereby generating additional •OH to destroy bacteria. Interestingly, Cu SASs/NPC can act as GSH peroxidase (GSH-Px)-like nanozymes, which can deplete GSH in bacteria, thereby significantly improving the sterilization effect. PTT-catalytic synergistic antibacterial strategy produces almost 100% antibacterial efficiency against Escherichia coli ( E. coli ) and methicillin-resistant Staphylococcus aureus ( MRSA ). In vivo experiments show a better PTT-catalytic synergistic therapeutic performance on MRSA-infected mouse wounds. Overall, our work highlights the wide antibacterial and anti-infective bio-applications of Cu single-atom-containing catalysts.

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Large-scale, high-purity, and uniform one-dimensional Ag 2 MO 4 (M ) Cr, Mo, and W) were obtained by a facile hydrothermal method. The as-prepared Ag 2 MO 4 materials exhibited linear current-voltage (I-V) characteristics and excellent photoresponse. As the light source was switched on and off, the currents could be reversibly switched between high and low value at the voltage of 0.1 V. Thus, the results suggested that the light-to dark-conductivity ratios of these compounds were correlated with the ionic potential of the metal. The extension of the photoresponses to silver silicate and silver vanadate also showed similar exciting results, indicating their potential applications in photoswitch devices in the future.

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