An acryl monomer containing the quinolone moiety was synthesized and then polymerized with azobisisobutyronitrile in a dimethylformamide solution. The resulting polymer as well as the corresponding monomer exhibited an excellent antibacterial activity. The poly(acrylated quinolone) (PQ) was compounded with other ordinary synthetic polymers such as low-density polyethylene (LDPE), poly(butylene succinate) (PBS), poly(methyl methacrylate) (PMMA), maleated polypropylene (PPMA), and polycaprolactone (PCL). The polymer blends reduced the viable cell number significantly on contact during the shake flask test even when the PQ content was as low as 1 wt %.
Five monomers with azole moieties were synthesized and their antimicrobial activities were investigated. The antimicrobial activity of the monomers was evaluated by the halo zone test method. The results strongly depended on the chemical structure of the group attached to the azole moieties. Polymers with (benzimidazol-2-yl)thio groups and with (5-methyl-1,3,4-thiadiazol-2-yl)thio groups were synthesized. The shake flask test showed that the two polymers possessed excellent antimicrobial activity.
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