Highlights d Ab induces metabolic reprogramming of microglia from OXPHOS to glycolysis d Metabolic reprogramming of microglia is dependent on the mTOR-HIF-1a pathway d Chronic exposure to Ab induces metabolic defects of microglia d Metabolic boosting with IFN-g restores immunological function of microglia

Graphene quantum dots (GQDs) have attracted great attention as next-generation luminescent nanomaterials due to the advantages of a low-cost process, low toxicity, and unique photoluminescence (PL). However, in the solid-state, the strong π−π stacking interactions between the basal planes of GQDs lead to aggregation-caused PL quenching (ACQ), which impedes practical application to light-emitting devices. Here, surface functionalized GQDs (F-GQDs) by polyhedral oligomeric silsesquioxane (POSS), poly(ethylene glycol) (PEG), and hexadecylamine (HDA) to reduce π−π stacking-induced ACQ is presented. The POSS-, PEG-, and HDA-functionalized GQDs show a significant enhancement in PL intensity compared to bare GQDs by 9.5-, 9.0-, and 5.6-fold in spin-coated film form and by 8.3-, 7.2-, and 3.4-fold in drop-casted film form, respectively. Experimental results and molecular dynamics simulations indicate that steric hindrance of the functionalization agent contributes to reducing the π−π stacking between adjacent GQDs and thereby enabling quenching-resistant PL in the solid-state. Moreover, the GQD-based white light-emitting diodes fabricated by mounting HDA-GQDs on a UV-LED chip exhibits efficient downconversion for white light emission with a high color rendering index of 86.2 and a correlated-color temperature of 5612 K at Commission Internationale de l'Éclairage coordinates of (0.333, 0.359).

Recent advances in big data technology collecting and analyzing large amounts of valuable data have attracted a lot of attention. When the information in non-reachable areas is required, IoT wireless sensor network technologies have to be applied. Sensors fundamentally have energy limitations, and it is almost impossible to replace energy-depleted sensors that have been deployed in an inaccessible region. Therefore, moving healthy sensors into the sensing hole will recover the faulty sensor area. In rough surfaces, hopping sensors would be more appropriate than wheel-driven mobile sensors. Sensor relocation algorithms to recover sensing holes have been researched variously in the past. However, the majority of studies to date have been inadequate in reality, since they are nothing but theoretical studies which assume that all the topology in the network is known and then computes the shortest path based on the nonrealistic backing up knowledge—The topology information. In this paper, we first propose a distributed hopping sensor relocation protocol. The possibility of movement of the hopping sensor is also considered to recover sensing holes and is not limited to applying the shortest path strategy. Finally, a performance analysis using OMNeT++ has demonstrated the solidification of the excellence of the proposed protocol.

The maintenance of genetic integrity is critical for stem cells to ensure homeostasis and regeneration. Little is known about how adult stem cells respond to irreversible DNA damage, resulting in loss of regeneration in humans. Here, we establish a permanent regeneration loss model using cycling human hair follicles treated with alkylating agents: busulfan followed by cyclophosphamide. We uncover the underlying mechanisms by which hair follicle stem cells (HFSCs) lose their pool. In contrast to immediate destructive changes in rapidly proliferating hair matrix cells, quiescent HFSCs show unexpected massive proliferation after busulfan and then undergo large-scale apoptosis following cyclophosphamide. HFSC proliferation is activated through PI3K/Akt pathway, and depletion is driven by p53/p38-induced cell death. RNA-seq analysis shows that HFSCs experience mitotic catastrophe with G2/M checkpoint activation. Our findings indicate that priming mobilization causes stem cells to lose their resistance to DNA damage, resulting in permanent loss of regeneration after alkylating chemotherapy.

Triarylboron emitters with secondary perfluoro acceptors display strong thermally activated delayed fluorescence (TADF) with high PLQYs up to 100%. TADF-OLEDs with the emitters achieve a high EQE of 29.9%, as well as an ultrahigh PE of 123.9 lm W−1.