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Berdasarkan survey pada 10 santri Pondok Pesantren Sunan Drajad, Lamongan, 9 diantaranya tidak memiliki pola makan yang baik. Hal-hal ini meningkatkan risiko seseorang menjadi gemuk, overweight, bahkan obesitas. Berdasarkan analisis situasi diatas, penyuluhan mengenai pola hidup dan makan yang sehat sangat diperlukan untuk mencegah resiko penyakit yang tidak diinginkan. Pengabdian masyarakat ini dilakukan dengan metode penyuluhan kepada siswa sekolah menengah atas yang dihadiri oleh tenaga kesehatan yang berasal dari dokter pengajar dan mahasiswa kedokteran Universitas Nahdlatul Ulama Surabaya. Hasil yang didapatkan cukup memuaskan, peserta sangat antusias, dan aktif menjawab pertanyaan yang diberikan. Dilihat dari feedback peserta dapat dikatakan kegiatan penyuluhan ini berhasil. Dari hasil kegiatan yang dilakukan, dapat disimpulkan bahwa pengetahuan untuk meningkatkan kesadaran dalam berperilaku hidup sehat dan menerapkan pola makan yang sehat sudah diterima dengan baik oleh peserta. Program ini diharapkan dapat dilakukan secara berkala sehingga dapat terus menambah wawasan masyarakat mengenai kesehatan.

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Introduction: Sambiloto plant (Andrographis paniculata) is often used as herbal medicine plant in Indonesia. Previous evidence indicates the use of a whole plant or single-compound approach. Analysis of multi-compounds is needed to determine the therapeutic potential for standardizing herbal medicine to provide a reliable effect. Methods: An exploratory study searching for the active content of A. paniculata was carried out in the Knapsack program. The chemical structure is analyzed computationally using Prediction of Activity Spectra for Substances (PASS) software. The analysis of the mechanism of action of drug molecules was analyzed using the Search Tool for Interacting Chemicals (STITCH) software. Results: The active content of A. paniculata is 46 types, with 5 of them having 6 effects based on chemical bonds and targeting 12 receptor proteins. Five active contents of A. paniculata include andrographidin A, caffeic acid, chlorogenic acid, wogonin 5-glucoside, and cinnamic acid. Analysis of the mechanism of action of A. paniculata based on 12 target proteins from active ingredients using a multi-compound approach shows 6 unique biological processes. Based on the chemical bonds, 5 active contents of A. paniculata have six effects, including anaphylatoxin receptor antagonist, a beta-adrenergic receptor kinase inhibitor, GABA C receptor agonist, G-protein-coupled receptor kinase inhibitor, Aryl hydrocarbon receptor agonist, and Nicotinic alpha6beta3beta4alpha5 receptor antagonist. Conclusion: There is a therapeutic potential of A. paniculata with multi-compounds analysis. A molecular docking analysis is needed to predict the affinity between the ligand (active ingredient) and the target protein.

This study was aimed to analyze multiple strategies for reducing open defecation in Pasuruan Regency, East Java, Indonesia. Breakthroughs and innovative policies are needed to accelerate the achievement of stopping open defecation behavior. Based on reports from the Pasuruan Health Office, several factors can cause people to stop practicing open defecation, such as enough amount of toilet and the increasing awareness of health and cleanliness. Da'i is an Islamic religious leader who is close to the community. Da"i educates people about Islam and invites people to do good deed based on Islamic rules. The people in Pasuruan has a robust Islamic boarding school background, so Da"i might have a big role in their way of living.