No abstract

SummaryBackground and objectives CKD is associated with poor cardiorespiratory fitness (CRF). This predefined substudy determined the effect of exercise training and lifestyle intervention on CRF and explored the effect on cardiovascular risk factors and cardiac and vascular function. Results Ten percent of randomized patients had subclinical myocardial ischemia at screening and completed the study without incident. There was no baseline difference among 72 patients who completed follow-up (36 in the lifestyle intervention group and 36 in the control group). The intervention increased peak _ VO 2 (2.860.7 ml/kg per minute versus 20.360.9 ml/kg per minute; P=0.004). There was small weight loss (21.864.2 kg versus 0.763.7 kg; P=0.02) but no change in BP or lipids. Diastolic function improved (increased e' of 0.7561.16 cm/s versus 20.4761.0 cm/s; P=0.001) but systolic function was well preserved and did not change. The change in arterial elastance was attenuated (0.1160.76 mmHg/ml versus 0.7660.96 mmHg/ml; P=0.01). D peak _ VO 2 was associated with group allocation and improved body composition.Conclusions Exercise training and lifestyle intervention in patients with CKD produces improvements in CRF, body composition, and diastolic function.

No abstract