132 Background: Social media has emerged as a powerful vehicle for the dissemination of medical information, especially in resource-limited regions, due to its mass global reach. However, 1/3 of social media posts contain misinformation with 76.9% of them containing harmful information leading to adverse outcomes that are a detriment to global public health. To address this, MedNews Week (MNW), a free, digital medical education platform dedicated to combating healthcare misinformation, was developed to contribute to global oncology education through biweekly programming. Its main show, Keynote Conference, features live virtual presentations from oncology’s premier global leaders discussing the latest developments in cancer before a mainstream global audience. The aim of this study was to assess the worldwide reach and impact of this cost-free, virtual oncology education platform. Methods: From January 2022 to 2023, MNW hosted 25 global oncology leaders as Keynote Speakers (Mean H-index=50.09). Viewership, impressions, and outreach data were collected from MNW’s social media accounts and TweepMaps. Data was analyzed to assess MNW’s global reach and engagement and stratified based on engagement sentiment, gender, age group, and occupation. Results: During this period, MNW generated a Healthcare Social Graph Score of 92.77% (top 7.33 percentile of global healthcare influencers) with over 109,128 Twitter impressions and 4,731 engagements reaching 1.9 million accounts globally over 12 months (Table). Most of the followers were from non-healthcare fields with slightly more males than females. Those who engaged conveyed positive sentiments (59.9% likes and 26.2% mentions) contributing to a viewership increase from 72,136 (6 months) to 157,559 (1 year). The platform reached 100 cities and 57 countries of which 16 were of low-to-middle socioeconomic (SE) status. Conclusions: MNW has demonstrated an ability to attract and sustain a diverse, global, growing audience. Given MNW’s continued growth, it provides an innovative model to engage and disseminate medical information to mainstream audiences. The platform’s ability to showcase global leaders to mainstream audiences gratuitously, especially in lower SE regions that have been historically underserved, offers a practical approach to combat educational inequity. Thus, MNW represents a novel approach with promising potential to positively impact global oncology education.[Table: see text]
139 Background: While the popularity of social media has grown as a source of healthcare news, studies have shown that one third of social media posts contain misinformation with 76.9% of them containing harmful information leading to adverse outcomes. As a result, MedNews Week (MNW), a digital platform dedicated to combating misinformation, was developed to contribute to global oncology education through its free programming. In its first year, MNW has connected 193,000 live viewers from 57 countries with opportunities to learn from and engage live with oncology’s global leaders during their Keynote Lectures. The goal of this study was to assess whether Twitter Impressions, LinkedIn Impressions and Speaker H-Index significantly predicted the number of live attendees at Keynote Lectures as a marker for the utilization of medical information resources by a global network of patients and patient advocates. Methods: In 2022, MNW hosted 32 distinguished physician-researchers as Keynote Speakers for live streamed virtual lectures of which 25 spoke on oncology topics. Twitter and LinkedIn promotional posts for each Keynote Lecture began one week before every event and the number of impressions were collected. The number of virtual attendees at each live lecture and speaker h-index (a common metric of scholarly impact) were recorded for each lecturer for statistical testing. Multiple linear regression was performed using R. Results: Results showed that the overall regression was statistically significant (R2 = 0.9977, F(3, 18) = 2650, p-value < 0.001). Twitter and LinkedIn Impressions significantly predicted the number of live attendees at Keynote Lectures (p-value < 0.001). However, the speaker H-index did not significantly predict the number of live Keynote attendees (p-value = 0.258 > 0.05). Conclusions: There is very strong evidence to support social media engagement as a predictor of health resource utilization as evident by Keynote Lecture attendance. However, a speaker’s H-index was not found to be a good predictor of health resource utilization by patients and patient advocates. The results of this analysis highlight the importance of traditional resources of medical knowledge adapting to the current digital climate, as platforms like MNW and COSMO demonstrate the growing impact of social media as an outlet for patient education and outreach – particularly in underserved regions globally.[Table: see text]
It is unknown whether interactions between tuft cells and trigeminal sinonasal neurons contribute to allergic disease. Intranasal administration of house dust mite or fungal allergens induced tuft cell expansion, eosinophilia, sneezing, Type 2 responses, and neuropeptide release. Mice lacking tuft cells lost these responses but retained eosinophilia and elevated neuropeptides. Ablation of Transient Receptor Potential Channel Vanilloid 1 (TRPV1)+ neurons prevented allergen-evoked tuft cell expansion and eosinophilia without affecting ILC2 and TH2 cell recruitment. Exposure of naive TG neurons to allergen evoked calcium influx and neuropeptide release, but only Substance P (SP) adaptively increased upon repetitive allergen exposure. SP instructed tuft cell lineage commitment and initiated allergic inflammation. Ablation or inhibition of the SP receptor, neurokinin 1, reversed allergen-induced sneezing, tuft cell expansion, and eosinophilia. We propose that sinonasal nociceptors detect protease-containing allergens and adaptively secrete SP to drive tuft cell expansion and early features of Type 2 immunity.
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