Epinephrine and the N6-O2'-dibutyryl analog of adenosine-3', 5'-cyclic phosphate both are effective inducers of tyrosine-alpha-ketoglutarate transaminase in explants of fetal rat liver maintained in organ culture. Combinations of these inducers with each other and with hydrocortisone, another inducer, yielded results which suggest that cyclic adenylic acid is an intermediate in the induction by epinephrine and that the mechanism by which it induces is different from that by which hydrocortisone operates.
Within 70 minutes after the administration of testosterone to rats castrated 12 to 15 hours previously, the rate of synthesis of RNA in the seminal vesicle is increased by 50 percent and continues to rise until approximately 50 minutes after injection when a two- to threefold increase was attained. No further increase was detected for as long as 240 minutes after hormone administration. The base composition of the pulse-labeled RNA was intermediate between that of the total seminal vesicle RNA and DNA-like RNA. No change in this composition was detected at any interval after injection.
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